Clinical profile and outcomes of COVID-19 infection during the first wave in children with hematological illnesses and cancer: An observational study from a tertiary care center in North India

Background: Patients with cancer are at a higher risk of getting infected with the severe acute respiratory syndrome coronavirus 2 owing to their immunocompromised state. Providing care to these patients amidst the first wave of the coronavirus disease-2019 (COVID-19) pandemic was extremely challenging. Objective(s): This study was aimed at evaluating the clinical profile and disease-related outcomes of pediatric patients with hematological illnesses and cancer. Material(s) and Method(s): This retrospective study was conducted at a tertiary care center in North India during the first wave of the pandemic from March 2020 to December 2020. Children aged up to 18 years, who were treated for a hematological illness or malignancy or underwent hematopoietic stem cell transplantation (HSCT) and tested positive for COVID-19 regardless of symptoms were included in the study. Baseline demographic data related to the age, diagnosis, treatment status, and chemotherapy protocol used were collected. Outcomes including the cure rates, comorbidities, and sequelae were recorded. Result(s): A total of 650 tests for COVID-19 were performed for 181 children;22 patients were found to be COVID-19 positive. The most common diagnosis was acute leukemia (63.6%). None of the patients developed COVID-19 pneumonia. The majority of patients had asymptomatic infection and were managed at home. Among those with a symptomatic infection, the most common symptoms were fever and cough. A total of 3 (13.6%) patients needed oxygen therapy, one developed multisystem inflammatory syndrome of children leading to cardiogenic shock. Three patients required intensive care or respiratory support;all the patients had favorable clinical outcomes. The median time from the onset of COVID-19 to a negative result on the reverse transcription-polymerase chain reaction test was 21.3 days. Cancer treatment was modified in 15 patients (68.2%). Conclusion(s): Our results suggest that children with hemato-oncological illnesses rarely experience severe COVID-19 disease. The impact of the first wave of COVID-19 primarily manifested as disruptions in the logistic planning and administration of essential treatment to these children rather than COVID-19 sequelae.Copyright © 2021 Cancer Research, Statistics, and Treatment Published by Wolters Kluwer - Medknow.

Macroeconomic impact of the supply shock during COVID-19 pandemic in India

Purpose: The study focuses on examining the impact of the supply shock on the Indian macroeconomic variables during the COVID-19 period. Design/methodology/approach: Time-varying factor augmented vector autoregressive model has been employed to study the asymmetry in transmission of supply shock on Indian economy during pre- and post-COVID-19 times. Findings: The authors find that with supply shock, retail food inflation outpaced in COVID-19 times. Production levels reported by IIP fell to abysmally low levels in the post-COVID-19 times when the economy stalled. The liquidity stimulus provided by the central bank led to the negative response of policy rates to the supply shocks during the COVID-19 times. Originality/value: The study stands novel in examining the impact of COVID-19 pandemic on Indian economy through the lenses of asymmetric transmission of supply shock during pre- and post-COVID-19 times. © 2023, Emerald Publishing Limited.

Unique Challenges Faced by a Child with Standard Risk Leukemia in Post-COVID Era: A Case Report

Children with malignancies are facing new challenges in post-COVID-19 era. We report an interesting case of a child on treatment for acute lymphoblastic leukemia having a very protracted course of illness with complications not often seen with standard therapy. It intends to make pediatric oncologists and intensive care specialists wary of potential newer complications.

Spanish flu to covid-19: Healthcare challenges and evolution

Spanish Flu (1918-1919) is considered the deadliest Pandemic of the twentieth century, with worldwide mortality of about 50 million people. One hundred years after this Pandemic, WHO had released a pandemic preparedness plan in March 2018 and urged all countries to have planned their response to future pandemics threats. This plan is a guide to building the capacity to face healthcare and economic challenges encountered during any pandemic. Today, in 2020, the world is witnessing Pandemic by another virus called COVID-19. This infection originated in China and has traveled globally to affect almost all countries. Healthcare worldwide in this Pandemic faces many challenges as expected, but the response and resilience in meeting these challenges have been exemplary. HealthCare technological and laboratory advancement has enabled full genomic sequencing within two weeks and the manufacture of trial vaccines within eight weeks. From creating makeshift hospitals and community isolation facilities, manufacturing medical equipment to providing accessible, affordable public health and information are depicting strong political will and motivation to fight this pandemic. This pandemic has also highlighted the gaps in pandemic preparedness among countries and provided them the opportunity to reflect on their healthcare needs and policies.